神经炎症与神经退行性疾病

 在脑损伤、感染等应激条件的诱导下，中枢神经系统中的小胶质细胞会迅速活化并促进神经炎症的发生。神经退行性疾病中同样存在广泛的慢性神经炎症，神经炎症还可能直接参与诱导了疾病的发生。对阿尔茨海默病等多种神经退行性疾病中炎症的活化机制，以及炎症如何诱导疾病发生和加重疾病进程的前沿研究进展进行了综述。提出找到那些靶向小胶质细胞活化关键位点，并具有良好血脑屏障通透性的药物是下一步的重点研究目标。

Neuroinflammation & neurodegenerative diseases

With the induction under the stress conditions such as the brain injury and the infection, the microglia in the central nervous system will rapidly be activated to promote the neuroinflammation. Extensive chronic neuroinflammation can be found in neurodegenerative diseases, and the abnormal folding protein deposited in the brain of patients is usually the key cause of inflammation. In addition, the neuroinflammation may also directly participate in the induction of the disease. This paper reviews the mechanisms underlying the activation of inflammation in multiple neurodegenerative diseases, as well as cutting-edge studies of how the inflammation induces the disease initiation and aggravates the disease process. It is suggested that the next key research goal is to find the drugs that target the key sites of the microglia activation with a good blood-brain barrier permeability.