The evolution, complex structures and function of septin proteins |
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Authors: | Lihuan Cao Wenbo Yu Yanhua Wu Long Yu |
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Institution: | (1) State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 200433 Shanghai, People’s Republic of China; |
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Abstract: | The septin family is a conserved GTP-binding protein family and was originally discovered through genetic screening for budding
yeast mutants. Septins are implicated in many cellular processes in fungi and metazoa. The function of septins usually depends
on septin assembling into oligomeric complexes and highly ordered polymers. The expansion of the septin gene number in vertebrates
increased the complex diversity of septins. In this review, we first discuss the evolution, structures and assembly of septin
proteins in yeast and metazoa. Then, we review the function of septin proteins in cytokinesis, membrane remodeling and compartmentalization. |
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Keywords: | |
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