Faithful after break-up: suppression of chromosomal translocations |
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Authors: | Sang Eun Lee Kyungjae Myung |
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Institution: | (1) Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, USA;(2) Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA |
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Abstract: | Chromosome integrity in response to chemically or radiation-induced chromosome breaks and the perturbation of ongoing replication
forks relies on multiple DNA repair mechanisms. However, repair of these lesions may lead to unwanted chromosome rearrangement
if not properly executed or regulated. As these types of chromosomal alterations threaten the cell’s and the organism’s very
own survival, multiple systems are developed to avoid or at least limit break-induced chromosomal rearrangements. In this
review, we highlight cellular strategies for repressing DNA break-induced chromosomal translocations in multiple model systems
including yeast, mouse, and human. These pathways select proper homologous templates or broken DNA ends for the faithful repair
of DNA breaks to avoid undesirable chromosomal translocations. |
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