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Pedigree transmission disequilibrium test for QTL mapping of threshold trait
作者姓名:DINGXiangdong  ZHANGQin  XURuhai  WANGYachun
作者单位:TheKeyLaboratoryofAnimalGeneticsandBreedingoftheMinistryofAgriculture,Beijing100094//StateKeyLaboratoryforAgrobiotechnology,Beijing100094,China
摘    要:With biological and economic importance,threshold traits are discrete in phenotype but have the same polygenic genetic basis as quantitative traits. The traditional linkage analysis for quantitative traits is invalid for threshold traits due to their special characters. The transmission disequilibrium test (TDT) has received great attention recently in localizing human disease genes due to its simplicity and powerfulness. But TDT only deals with data from independent nuclear families and it will lose information about extended pedigree that incorporates information not only from parents and siblings but also from other relatives. The pedigree disequilibrium test (PDT) proposed by Martin in 2001 can be used to analyze the extended pedigree in human.In this study, PDT was introduced into the QTL mapping of threshold traits for farm animals, and was modified in order to accommodate the pedigree structures of farm animals.The modified PDT was renamed pedigree transmission disequilibrium test (PTDT) and its power and type I error were investigated and compared with that of PDT by Monte Carlo simulation. It was shown that PTDT is a robust and valid approach to mapping QTL of threshold trait. When the parental information is complete, PTDT and PDT are almost the same in terms of power and type I error. However, if the parental information is missing to a certain extent, PTDT is higher in power and lower in type I error than PDT. These results imply that PTDT can be a novel approach to QTL fine mapping of threshold traits based on the existing coarse mapping information.

关 键 词:QTL图  阈值性状  多基因遗传  血统不稳定试验  血统结构
收稿时间:2004-02-02
修稿时间:2004-06-02

Pedigree transmission disequilibrium test for QTL mapping of threshold trait
DINGXiangdong ZHANGQin XURuhai WANGYachun.Pedigree transmission disequilibrium test for QTL mapping of threshold trait[J].Chinese Science Bulletin,2004,49(13):1347-1353.
Authors:Xiangdong Ding  Qin Zhang  Ruhai Xu  Yachun Wang
Institution:(1) The Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, 100094 Beijing;(2) State Key Laboratory for Agrobiotechnology, 100094 Beijing, China
Abstract:With biological and economic importance, threshold traits are discrete in phenotype but have the same polygenic genetic basis as quantitative traits. The traditional linkage analysis for quantitative traits is invalid for threshold traits due to their special characters. The transmission disequilibrium test (TDT) has received great attention recently in localizing human disease genes due to its simplicity and powerfulness. But TDT only deals with data from independent nuclear families and it will lose information about extended pedigree that incorporates information not only from parents and siblings but also from other relatives. The pedigree disequilibrium test (PDT) proposed by Martin in 2001 can be used to analyze the extended pedigree in human. In this study, PDT was introduced into the QTL mapping of threshold traits for farm animals, and was modified in order to accommodate the pedigree structures of farm animals. The modified PDT was renamed pedigree transmission disequilibrium test (PTDT) and its power and type I error were investigated and compared with that of PDT by Monte Carlo simulation. It was shown that PTDT is a robust and valid approach to mapping QTL of threshold trait. When the parental information is complete, PTDT and PDT are almost the same in terms of power and type I error. However, if the parental information is missing to a certain extent, PTDT is higher in power and lower in type I error than PDT. These results imply that PTDT can be a novel approach to QTL fine mapping of threshold traits based on the existing coarse mapping information.
Keywords:threshold trait  QTL mapping  pedigree transmission disequilibrium test  extended pedigree  
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