Structure revision and cytotoxicity of the germacranolide,stizolicin, fromStizolophus balsamitus (Asteraceae) |
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| Authors: | J M Cassady M F Bean J L McLaughlin Y Aynehchi |
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| Institution: | (1) Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, 47907 West Lafayette, Indiana, USA;(2) Present address: College of Pharmacy, University of Tehran, Tehran, Iran |
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| Abstract: | Summary The structure of the cytotoxic sesquiterpene lactone, stizolicin, reisolated fromStizolophus balsamitus (Centaurea b.) was revised to atrans, trans germacranolide (1) on the basis of simultaneous application of lanthanide shift reagent and NOE in the NMR.The authors acknowledge the use of the Purdue University Biomedical Magnetic Resonance Laboratory (NIH grant No. RR01077). Support of contract No. N01-CM-97296 and Grant No. CA-33326 from the National Cancer Institute, HHS is gratefully acknowledged. This is paper 18 in the series  Potential Antitumor Agents . |
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| Keywords: | Stizolicin germacranolide Stizolophus balsamitus Asteraceae structure revision |
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