| 金属离子与血清白蛋白结合反应研究进展 |
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| 引用本文： | 秦身钧,申金山,李艳廷,魏永巨. 金属离子与血清白蛋白结合反应研究进展[J]. 河北师范大学学报(自然科学版), 2003, 27(1): 75-80 |
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| 作者姓名： | 秦身钧 申金山 李艳廷 魏永巨 |
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| 作者单位： | 河北师范大学,化学学院,河北,石家庄,050016 |
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| 基金项目： | 河北省自然科学基金资助项目(200153)，河北省教育厅博士基金资助项目 |
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| 摘 要： | 综述了金属离子与血清白蛋白结合反应的研究进展，简要介绍了研究中常用的紫外－可见光谱法、荧光光谱法以及平衡透析法。根据已发表的研究结果，对某些金属离子与血清白蛋白结合的位点、络合物的空间构型、结合数和稳定常数进行了总结，对金属离子与血清白蛋白之间的强结合位点进行了分类。最后讨论了此类研究中存在的问题和研究方向。
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| 关 键 词： | 结合反应 研究进展 血清白蛋白 金属离子 紫外－可见光谱 荧光光谱 平衡透析 结合位点 |
| 文章编号： | 1000-5854(2003)01-0075-06 |
Development of the Study of Interaction Between Metal Ions and Serum Albumin |
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| QIN Shen-jun,SHEN Jin-shan,LI Yan-ting,WEI Yong-ju. Development of the Study of Interaction Between Metal Ions and Serum Albumin[J]. Journal of Hebei Normal University, 2003, 27(1): 75-80 |
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| Authors: | QIN Shen-jun SHEN Jin-shan LI Yan-ting WEI Yong-ju |
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| Abstract: | The study of interaction between metal ions and proteins is a new frontier of chemistry and life science. About the interaction between metal ions and serum albumin is given. Methods frequently used in the study, such as ultraviolet spectroscopy, fluorescence spectroscopy and equilibrium dialysis, are briefly introduced. According to the reported results available nowadays, binding sites of metal ions on protein, space configuration, binding number and stability constants of metal-protein complex are summarized, and the strong binding sites between metal ions and serum albumin are classified. At last, the existing problems and studying tendency of this field are discussed. |
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| Keywords: | serum albumin metal ions ultraviolet spectroscopy fluorescence spectroscopy equilibrium dialysis |
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