| 脱落细胞端粒酶活性对恶性肿瘤的诊断价值 |
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| 引用本文： | 胡远贵,沈云峰,马丹. 脱落细胞端粒酶活性对恶性肿瘤的诊断价值[J]. 江汉大学学报(自然科学版), 2003, 31(4): 82-84 |
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| 作者姓名： | 胡远贵 沈云峰 马丹 |
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| 作者单位： | 江汉大学,附属医院检验科,湖北,武汉,430015 |
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| 摘 要： | 目的:检测恶性肿瘤病人体液中端粒酶的活性,以探讨其临床意义. 方法:采用端粒酶PCR-ELISA 法对27例恶性肿瘤及51 例良性疾病病人的支气管灌洗液、胸水、腹水、尿液的端粒酶活性进行对比研究. 结果:恶性肿瘤组织其端粒酶的检出率显著高于对照组.结论:端粒酶活性表达与肿瘤发生密切相关,将可能作为恶性肿瘤早期诊断的生物学指标.
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| 关 键 词： | 端粒酶活性 肿瘤 PCR-ELISA法 |
| 文章编号： | 1009-1777-(2003)04-0082-03 |
| 修稿时间： | 2003-03-27 |
The Diagnostic Value of the Telomerase Activity in Exfoliated Cell to the Malignant Tumor |
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| HU Yuan-gui,SHEN Yun-feng,MA Dan. The Diagnostic Value of the Telomerase Activity in Exfoliated Cell to the Malignant Tumor[J]. Journal of Jianghan University(Natural Sciences), 2003, 31(4): 82-84 |
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| Authors: | HU Yuan-gui SHEN Yun-feng MA Dan |
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| Abstract: | Object: To detect telomerase activity in body fluid of the malignant tumor patients and investigate its clinic evaluation. Methods: The twenty-seven cases of malignant tumor pa- tients and fifty-one benign patients were our detective objects. The methods of PCR-ELISA were used. We investigated the telomerase activity by contrast in the BALF, chest fluid, ab- domind fluid and urine. Results: The detectiable rates of the telomerase in the malignant tumor groups were significiantly higher than the objective groups. Conclusion: There are close asso- ciations between the expression of the telomerase activity and the malignant tumor. The telom- erase will be able to a biological index in early diagnosis of the malignant tumor. |
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| Keywords: | telomerase activity tumor PCR-ELISA |
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