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Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells |
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| Authors: | R Derynck J A Jarrett E Y Chen D H Eaton J R Bell R K Assoian A B Roberts M B Sporn D V Goeddel |
| Abstract: | The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. TGF-beta messenger RNA is synthesized in various normal and transformed cells. |
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