| 盐酸安非他酮的合成工艺研究 |
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| 引用本文： | 徐自奥,周伟斌,刘宏亮,李晓祥.盐酸安非他酮的合成工艺研究[J].安徽大学学报(自然科学版),2006,30(5):87-90. |
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| 作者姓名： | 徐自奥 周伟斌 刘宏亮 李晓祥 |
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| 作者单位： | 1. 安徽新星药物开发有限责任公司,安徽,合肥,230031
2. 安徽大学,化学化工学院,安徽,合肥,230039 |
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| 基金项目： | 安徽省“十五”科技攻关项目基金资助(01013037) |
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| 摘 要： | 盐酸安非他酮为一种抗抑郁药物.以间氯苯甲酰氯为原料,经酰化、格氏反应、溴化和N-烃基化反应得盐酸安非他酮.并运用元素分析、UV、IR、HNMR和MS进行结构确证.改进后的工艺总收率达50.8%(以间氯苯甲酰氯计).结果表明操作方法简便,总收率较高.
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| 关 键 词： | 盐酸安非他酮 间氯苯甲酰氯 中间体 合成 |
| 文章编号： | 1000-2162（2006）05-0087-04 |
| 收稿时间： | 2005-12-31 |
| 修稿时间： | 2005-12-31 |
Studies on the synthesis of bupropion hydrochloride |
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| XU Ziao,ZHOU Wei-bin,LIU Hong-liang,LI Xiao-xiang.Studies on the synthesis of bupropion hydrochloride[J].Journal of Anhui University(Natural Sciences),2006,30(5):87-90. |
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| Authors: | XU Ziao ZHOU Wei-bin LIU Hong-liang LI Xiao-xiang |
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| Institution: | 1. Anhui New Star Pharmaceutical Development Co. , Ltd , Hefei 230031, China; 2. School of Chemisty and Chemical Technology,Anhui University, Hefei 230039, China |
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| Abstract: | Bupropion hydrochloride is an antidepressant.m-chlorobenzoyl chloride takes for raw material in this artical.After through acylate,Grignard reaction,bromination,N-alkylation,the bupropion hydrochloride was obtained.The structures of the products were determined by elemental analysis,UV,IR,~(1)H-NMR,~(13)C-NMR and MS.the total yield of bupropion hydrochloride was 50.8% based on m-chlorobenzoyl chloride.The result shows that the method is convenient and the total yield is higher. |
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| Keywords: | bupropion hydrochloride m-chlorobenzoyl chloride intermediate synthesis |
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