| 2,5—二甲苯酚的O—烷基化反应 |
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| 引用本文： | 钟平 尹承烈. 2,5—二甲苯酚的O—烷基化反应[J]. 北京师范大学学报(自然科学版), 1992, 28(3): 379-382 |
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| 作者姓名： | 钟平 尹承烈 |
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| 作者单位： | 北京师范大学化学系，北京师范大学化学系 100875，北京新外大街，100875，北京新外大街 |
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| 摘 要： | 研究了2,5-二甲苯酚与1,3-二卤代丙烷及一卤代羧酸酯的O-烷基化反应.2,5-二甲苯酚与1,3-二溴丙烷在NaOH-H_2O,NaOH-甲苯-DMSO或无水K,CO_3-丙酮中反应,产物均为1-(2,5-二甲苯氧基)-3-溴丙烷,产率分别为59.8%,64.5%和74.0%.2,5-二甲苯酚与1-溴-3-氯丙烷在无水K_2CO_3-丙酮中反应,产物为1-(2,5-二甲苯氧基)-3-氯丙烷,产率为77.5%.上述产物的结构由~1HNMR和IR数据所确定.2,5-二甲苯酚与一卤代羧酸酯的反应产率在81%以上.
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| 关 键 词： | 二甲苯酚 二溴丙烷 O－烷基化 |
O-ALKYLATION OF 2,5-DIMETHYLPHENOL |
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| Zhong Ping Yin Chenglie. O-ALKYLATION OF 2,5-DIMETHYLPHENOL[J]. Journal of Beijing Normal University(Natural Science), 1992, 28(3): 379-382 |
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| Authors: | Zhong Ping Yin Chenglie |
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| Abstract: | The O-alkylation of 2,5-dimethylphenol with 1,3-dihalogen- propane and some monohalogen carboxylic esters are studied.In NaOH-H_2O, NaOH-toluene-DMSO or anhydrous K_2CO_3-acetone the O-alkylation of 2,5- dimethylphenol with 1,3-dibromopropane give 1-(2,5-dimethyl phenoxyl) -3-bromopropane,the yield is 59.8%,64.5% and 74% respectively.In anhy- drous K_2CO_3-acetone the O-alkylation of 2,5-dimethylphenol with 1-bromo -3-chloropropane give 1-(2,5-dimethyl phenoxyl)-3-chloropropane,the yield is 77.5%.The structures of resultants are mainly elucidated by spectrum methods(IR,~1HNMR).The yield of O-alkylation of 2,5-dimethylphenol with the monohalogen carboxylic esters is above 81%. |
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| Keywords: | 2 5-dimethylphenol 1 3-dibromopropane 1-bromo-3-chlo-ropropane monohalogen carboxylic ester O-alkylation yield |
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