Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice |
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Authors: | Kouznetsova Anna Lister Lisa Nordenskjöld Magnus Herbert Mary Höög Christer |
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Institution: | Department of Cell and Molecular Biology, Karolinska Institutet, S-171 77, Stockholm, Sweden. |
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Abstract: | The spindle assembly checkpoint guards against chromosomal missegregation but does not induce arrest in oocytes that contain a few achiasmatic chromosomes (univalents). We followed the fate of univalents in oocytes during the first meiotic division, and although these preserved a meiotic kinetochore structure, they were also bi-oriented in a mitotic manner. The hybrid chromosomal configuration attained by univalents allows them to evade the spindle assembly checkpoint and contribute to aneuploidy in oocytes. |
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