| 单纯胰液反流对食管粘膜损伤的实验研究 |
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| 引用本文： | 李达周,王雯,张志坚,王蓉,卢嘉臻.单纯胰液反流对食管粘膜损伤的实验研究[J].实验动物科学,2011,28(1):13-14,17,74. |
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| 作者姓名： | 李达周 王雯 张志坚 王蓉 卢嘉臻 |
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| 作者单位： | 1. 南京军区福州总医院消化科,福州,350025
2. 解放军第一七五医院消化科,漳州,363000 |
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| 摘 要： | 目的了解单纯胰液反流对食管粘膜的损伤作用。方法运用全胃切除＋食管十二指肠端侧吻合术＋胆管空肠吻合术制作单纯胰液食管反流,并于不同时间分批取得食管标本进行组织形态学研究。结果实验组均出现程度不等的反流性食管炎,病变以食管下段为重,随病程延长加重,组织学表现为炎症、糜烂溃疡、上皮高度增生及出现化生柱状上皮。结论胰液能造成明显食管粘膜损伤,可能在胃食管反流病（GERD）及并发症的发生中具有重要意义。
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| 关 键 词： | 胰液 食管炎 反流 |
Effects of Single Pancreatic Juice Reflux on Esophageal Mucosa |
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| LI Da-zhou,WANG Wen,ZHANG Zhi-jian,WANG Rong,LU Jia-zhen.Effects of Single Pancreatic Juice Reflux on Esophageal Mucosa[J].Shiyan Dongwu Kexue,2011,28(1):13-14,17,74. |
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| Authors: | LI Da-zhou WANG Wen ZHANG Zhi-jian WANG Rong LU Jia-zhen |
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| Institution: | LI Da-zhou1,WANG Wen1,ZHANG Zhi-jian1,WANG Rong1,LU Jia-zhen2(Department of Gastroenterology,Fuzhou General Hospital,Fuzhou 350025,China)(Department of Gastroenterology,No 175 Hospital Of PLA,Zhangzhou 363000,China) |
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| Abstract: | Objective To investigate the effects of single pancreatic juice reflux on esophageal mucosa,and to establish rat models of reflux esophagitis.Methods We produced esophagitis in two experimental groups of Sprague-Dawley rats: Group A,gastrectomy and end-to-side esophagojejunostomy and bile-duct-jejunostomy;Group B,control group.The esophageal samples were taken at different time after operation and studied.Results Most of the rats in reflux group displayed evidence of reflux esophagitis,which was more severe... |
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| Keywords: | Animal model Reflux esophagitis Pancreatic juice |
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