| 盐酸伊托必利临床常用剂量对大鼠酸性反流性食管炎模型的影响 |
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| 引用本文： | 向绍杰,刘冉,孟莉,乔敏,乔菊久,李淼. 盐酸伊托必利临床常用剂量对大鼠酸性反流性食管炎模型的影响[J]. 实验动物科学, 2011, 28(1): 15-17 |
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| 作者姓名： | 向绍杰 刘冉 孟莉 乔敏 乔菊久 李淼 |
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| 作者单位： | 1. 辽宁省中医药研究院,沈阳,110034
2. 辽宁出入境检验检疫局,大连,116001 |
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| 摘 要： | 目的探讨盐酸伊托必利临床常用剂量对大鼠酸性反流性食管炎模型的作用。方法采用不完全结扎幽门＋食管下括约肌切开术制备大鼠酸性反流性食管炎模型,观察盐酸伊托必利临床常用剂量对大鼠酸性反流性食管炎模型小肠推进及食管黏膜病理形态的影响。结果盐酸伊托必利能明显提高酸性反流性食管炎模型大鼠的小肠推进功能,明显减轻模型大鼠食管黏膜的损伤。结论盐酸伊托必利临床常用剂量对大鼠酸性反流性食管炎模型有明显的治疗作用。
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| 关 键 词： | 盐酸伊托必利 大鼠 酸性反流性食管炎 动物模型 |
Effects of Therapeutic Dose of Itopride Hydrochloride on Rat Animal Model with Acid Reflux Esophagitis |
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| XIANG Shao-jie,LIU Ran,MENG Li,QIAO Min,QIAO Ju-jiu,LI Miao. Effects of Therapeutic Dose of Itopride Hydrochloride on Rat Animal Model with Acid Reflux Esophagitis[J]. Laboratory Animal Science, 2011, 28(1): 15-17 |
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| Authors: | XIANG Shao-jie LIU Ran MENG Li QIAO Min QIAO Ju-jiu LI Miao |
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| Affiliation: | XIANG Shao-jie1,LIU Ran2,MENG Li1,QIAO Min1,QIAO Ju-jiu1,LI Miao1(1.Liaoning Traditional Chinese Medicine Institute,Shenyang 110034,China)(2.Liaoning Entry-Exit Inspection and Quarantine Bereau,Dalian 116001,China) |
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| Abstract: | Objective To observe effects of therapeutic dose of itopride hydrochloride on rat animal model with acid reflux esophagitis.Methods To study the effect of therapeutic dose of itopride hydrochloride on intestinal propulsion and pathological moriphology of esophagus mucosa with acid reflux esophagitis induced by pyloric partial ligation and cardiac sphincter dissection.Result The itopride hydrochloride has significant effect on intestinal propulsion function and relieve esophagus mucosa injury of rat animal m... |
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| Keywords: | Itopride hydrochloride Acid reflux esophagitis Animal model |
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