| 自发性糖尿病小鼠C57BL/KsJ-db/db某些脏器组织病理学观察 |
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| 引用本文： | 田小芸,董敏,赵志刚,许龙祥,刘彪,郭联庆,恽时锋. 自发性糖尿病小鼠C57BL/KsJ-db/db某些脏器组织病理学观察[J]. 实验动物科学, 2011, 28(1): 18-20,74 |
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| 作者姓名： | 田小芸 董敏 赵志刚 许龙祥 刘彪 郭联庆 恽时锋 |
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| 作者单位： | 南京军区南京总医院比较医学科,全国科普教育基地,南京,210002 |
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| 摘 要： | 目的观察自发性糖尿病C57BL/KsJ-db/db小鼠胰腺、肾脏、睾丸和卵巢的常规病理变化。方法取血糖高于10.1 mmol/L的2、7、12月龄db/db纯合仔小鼠,摘眼球放血后取胰腺、肾、睾丸、卵巢放入10%福尔马林溶液中,HE染色,常规病理切片。结果 7、12月龄胰腺见淋巴细胞浸润,部分胰岛体积较大,小导管样病变有增生扩张及潴溜;小鼠肾脏见部分肾小球细胞数增多,系膜细胞增生,系膜基质增多;卵巢较小,卵泡较少,未见黄体;睾丸生精功能弱。结论 C57BL/KsJ-db/db小鼠的自发性糖尿病会在一定程度上出现胰腺、肾脏、睾丸和卵巢等脏器发生病理改变。
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| 关 键 词： | 病理改变 糖尿病 小鼠 胰腺 肾脏 睾丸 卵巢 |
Pathological Changes of Some Organs in Spontaneous Diabetes C57BL/KsJ-db/db Mice |
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| TIAN Xiao-yun,DONG Ming,ZHAO Zhi-gang,XU Long-xiang,LIU Biao,GUO Lian-qing,YUN Shi-feng. Pathological Changes of Some Organs in Spontaneous Diabetes C57BL/KsJ-db/db Mice[J]. Laboratory Animal Science, 2011, 28(1): 18-20,74 |
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| Authors: | TIAN Xiao-yun DONG Ming ZHAO Zhi-gang XU Long-xiang LIU Biao GUO Lian-qing YUN Shi-feng |
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| Affiliation: | TIAN Xiao-yun,DONG Ming,ZHAO Zhi-gang,XU Long-xiang,LIU Biao,GUO Lian-qing,YUN Shi-feng(Department of Comparative Medicine,Nanjing General Hospital of Nanjing Military Command,Nanjing 210002,China) |
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| Abstract: | Objective To observe routine pathological changes of the pancreas,kidney,testis and ovary in spontaneous diabetic mice.Methods C57BL /KsJ-db /db mice with blood glucose over 10.1 mmol /L at 2,7 and 12 month entered this study,after sacrificed,their organs pancreas,kidney,testis and ovary were soaked in 10% formalin for HE coloration and general pathological section.Results At 7 or 12 month,the pancreas tissues had lymphocyte infiltration,partial pancreas islets size increase and condulet hyperplasy ectasia;... |
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| Keywords: | Pathological Changes Diabetes Mice Pancreas Kidney Testis Ovary |
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