Effect of free fatty acids and cholesterol in vitro on liver plasma membrane-bound enzymes |
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Authors: | S. Leoni P. Luly M. T. Mangiantini S. Spagnuolo |
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Affiliation: | (1) Institute of General Physiology, University of Rome, I-00185 Rome, (Italy) |
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Abstract: | Summary The effect of cholesterol and fatty acid treatment in vitro was tested on rat liver plasma membrane-bound enzymes and lipid fluidity. The observed alterations of membrane fluidity affect both (Na+–K+)-ATPase and Mg2+-ATPase activities but not 5 -nucleotidase; basal adenylate cyclase as well as its hormonal sensitivity were differentially affected by changes of membrane microenvironment.This investigation was partially supported by the Italian National Research Council. |
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