Methoxyphenylethylamines as substrates for type A and type B monoamine oxidase |
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| Authors: | O Suzuki T Matsumoto Y Katsumata M Oya |
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| Institution: | (1) Department of Legal Medicine, Hamamatsu University School of Medicine, 431-31 Hamamatsu, (Japan);(2) Division of Oncology, First Department of Surgery and Department of Legal Medicine, Nagoya University School of Medicine, 466 Nagoya, (Japan) |
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| Abstract: | Summary 4-Methoxyphenylethylamine was found to be a specific substrate for type B monoamine oxidase (MAO) in rat brain mitochondria, whereas 3,4-dimethoxyphenylethylamine was common for both types of MAO. These results suggest that O-methylation in the para-position increases the preference of the substrate for type B MAO, while a methoxy-group in the meta-position contributes to the substance being a type A substrate. |
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