Regional brain [Met]-enkephalin in alcohol-preferring and non-alcohol-preferring inbred strains of mice |
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| Authors: | K. Blum A. H. Briggs J. E. Wallace C. W. Hall M. A. Trachtenberg |
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| Affiliation: | (1) Departments of Pharmacology and Pathology, University of Texas Health Science Center, 77058, Texas, USA;(2) Departments of Pharmacology and Pathology, Southwest Research Institute, 78 284 San Antonio, Texas, USA;(3) Departments of Pharmacology and Pathology, Matrix Technologies, Inc., 77058 Houston, Texas, USA |
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| Abstract: | Summary Scrutiny of the data from these studies reveals that the C58/J alcohol-preferring mice have significantly lower baseline methionine-enkephalin levels in both the corpus striatum and hypothalamus compared to C3H/CHRGL/2 non-alcohol-preferring mice. In other brain regions in these two strains, specifically, pituitary, amygdala, midbrain, and hippocampus, analysis of methionine-enkephalin levels did not show any significant differences. This suggests that the hypothalamus may indeed be a specific locus involved in the regulation of alcohol intake, via the molecular interaction between neuroamines, opioid peptides, as they are influenced by genetics and environment. |
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| Keywords: | Opioid peptides methionine-enkephalin alcohol-avoiding mice alcohol-preferring mice hypothalamus corpus striatum |
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