The effect of endotoxin on membrane fatty acid composition in BCG-sensitized mice |
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| Authors: | J M Stark S K Jackson S Taylor I Davies J L Harwood |
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| Institution: | (1) Department of Medical Microbiology, University of Wales College of Medicine, Heath Park, CF4 4XN Cardiff, UK;(2) Department of Biochemistry, University of Wales College of Cardiff, Cathays Park, CF1 1ST Cardiff, (UK) |
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| Abstract: | Summary The effects of endotoxin on mouse liver phospholipid fatty acid composition have been investigated. Administration of endotoxin fromSalmonella abortus equi led to a decrease in the polyunsaturated fatty acid content of livers from mice sensitized with Bacille Calmette Guérin (GCG). The content of arachidonic acid fell significantly in both the phosphatidylcholine and phosphatidylinositol fractions whereas in the phosphatidylethanolamine fraction the linoleic acid content was significantly reduced. The polyunsaturated fatty acids were replaced by increased amounts of oleic acid and palmitic acid, leading to a reduction in the polyunsaturated to saturated fatty acid ratio. |
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| Keywords: | Endotoxin fatty acid phospholipid BCG |
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