Resistance of purified cholera toxin to enzymatic treatment with pancreatic elastase and papain |
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Authors: | G. Antoni I. Marsili P. Tarli P. Neri |
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Affiliation: | (1) Research Centre, I. S. V. T. Sclavo, Via Fiorentina 1, Siena, (Italy) |
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Abstract: | Summary Treatment of Cholera toxin with pancreatic elastase and papain in vitro shoed a high resistance of the toxin molecule to these enzymes, under non-denaturing conditions or in the presence of 2M urea. These experiments support the hypothesis of a particularly stable molecular structure of the toxin, as an explanation of its activity in the intestinal lumen where the pancreatic proteases are active. |
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