| RhoGTPases in stem cells |
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| 作者姓名： | YAO HaiLei XIE XiaoYan WANG DongMei PEI XueTao |
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| 作者单位： | Department of Stem Cells and Regenerative Medicine, Beijing Institute of Transfusion Medicine,Beijing 100850, China |
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| 基金项目： | Supported by State 863 High Technology R＆D Project of China （Grant No. 2006AA02A107） and the National Key Project for Basic Research of China （Grant No. 2005CB522702） |
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| 摘 要： |
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| 关 键 词： | 干细胞 自我更新能力 转换方式 调节作用 |
| 收稿时间： | 26 March 2007 |
| 修稿时间： | 2007-03-26 |
RhoGTPases in stem cells |
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| YAO HaiLei XIE XiaoYan WANG DongMei PEI XueTao.RhoGTPases in stem cells[J].Chinese Science Bulletin,2007,52(22):3025-3028. |
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| Authors: | Yao HaiLei Xie XiaoYan Wang DongMei Pei XueTao |
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| Institution: | (1) Department of Stem Cells and Regenerative Medicine, Beijing Institute of Transfusion Medicine, Beijing, 100850, China |
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| Abstract: | RhoGTPases are small molecules that control a wide variety of signal transduction pathways. Their profound function in regulating the actin cytoskeleton is well recognized. Stem cells are unique in their ability to self-renew and produce progenitor cells that can differentiate into specialized cells. RhoGTPases influence stem cell morphology and cell migration as well as stem cell self-renewal, proliferation, transplantation, homing and differentiation. In this review, the multiple roles of the RhoGTPases in stem cells are discussed. |
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| Keywords: | RhoGTPases stem cells self-renewal proliferation differentiation |
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