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Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci |
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| Authors: | Melum Espen Franke Andre Schramm Christoph Weismüller Tobias J Gotthardt Daniel Nils Offner Felix A Juran Brian D Laerdahl Jon K Labi Verena Björnsson Einar Weersma Rinse K Henckaerts Liesbet Teufel Andreas Rust Christian Ellinghaus Eva Balschun Tobias Boberg Kirsten Muri Ellinghaus David Bergquist Annika Sauer Peter Ryu Euijung Hov Johannes Roksund Wedemeyer Jochen Lindkvist Björn Wittig Michael Porte Robert J Holm Kristian Gieger Christian Wichmann H-Erich Stokkers Pieter Ponsioen Cyriel Y Runz Heiko Stiehl Adolf Wijmenga Cisca Sterneck Martina Vermeire Severine Beuers Ulrich |
| Affiliation: | Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway. |
| Abstract: | Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and 2,174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 × 10?1? and P = 4.1 × 10??, respectively). |
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