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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes |
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| Authors: | Todd John A Walker Neil M Cooper Jason D Smyth Deborah J Downes Kate Plagnol Vincent Bailey Rebecca Nejentsev Sergey Field Sarah F Payne Felicity Lowe Christopher E Szeszko Jeffrey S Hafler Jason P Zeitels Lauren Yang Jennie H M Vella Adrian Nutland Sarah Stevens Helen E Schuilenburg Helen Coleman Gillian Maisuria Meeta Meadows William Smink Luc J Healy Barry Burren Oliver S Lam Alex A C Ovington Nigel R Allen James Adlem Ellen Leung Hin-Tak Wallace Chris Howson Joanna M M Guja Cristian Ionescu-T?rgovi?te Constantin;Genetics of Type Diabetes in Finland Simmonds Matthew J Heward Joanne M |
| Institution: | Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0XY, UK. john.todd@cimr.cam.ac.uk |
| Abstract: | The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmune disease type 1 diabetes (T1D), shows associations at P < 5 x 10(-7) between T1D and six chromosome regions: 12q24, 12q13, 16p13, 18p11, 12p13 and 4q27. Here, we attempted to validate these and six other top findings in 4,000 individuals with T1D, 5,000 controls and 2,997 family trios independent of the WTCCC study. We confirmed unequivocally the associations of 12q24, 12q13, 16p13 and 18p11 (P(follow-up) |
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