环磷酰胺诱导小鼠骨髓嗜多染红细胞微核阳性率分析

对环磷酰胺（４０ｍｇ／ｋｇＢＷ）诱导昆明小鼠骨髓嗜多染红细胞微核率进行了统计分析，结果表明：微核率均值雌性为３１．６８，标准差为９．４１；雄性为２８．３２，标准差为７．６７，阴性对照组微核率均值雌性为１．７８，标准差为０．５５；雄性为１．６８，标准差为０．４５，环磷酰胺组（４０ｍｇ／ｋｇＢＷ）微核率与阴性对照同性别微核率相比，均有极显著性差异（Ｐ〈０．０１），经Ｆ检验，环磷胺组和阴性对照组每组雌，

Analysis of the Positive Rate of Micronucleus\= for mice Bone Marrow Cell Induced by Cyclophosphamide

Statistical analysis was done for the rate of micronucleus of bone marrow cell of Kunming mouse.induced by Cyclophosphamide (40 mg/kgBW) in our lab,the mouse were provided by Chinese Academic of Military Medicine.It showed that mean value of the rate of micronucleus for female is 31.68,standard deviation was 941,and for male was 2832,standard deviation was 7.67 in Cyclophosphamide group;In negative control group,mean value of the rate of micronucleus for female is 1.78,standard deviation was 0.55,and for male was 1.68,standard deviation was 0.45. In both group,there is not a significant difference between female and male (P>0.01).it is thought that rate of micronucleus induced by Cyclophosphamide were basically stable.It is applicable to use Cyclophosphamide (40mg/kgBW) to do positive test of micronucleus,and it is suggested that it be done only once per year.