| 力竭运动对大鼠脑纹状体5-HT含量及其代谢的影响 |
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| 引用本文： | 刘蓓蓓,张蕴琨.力竭运动对大鼠脑纹状体5-HT含量及其代谢的影响[J].南京体育学院学报(自然科学版),2008(1). |
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| 作者姓名： | 刘蓓蓓 张蕴琨 |
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| 作者单位： | 南京军区南京总医院康复医学科 南京体育学院教务处 江苏南京 江苏南京 |
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| 摘 要： | 目的:观察力竭运动对大鼠脑纹状体5-羟色胺(5-HT)含量及其代谢的影响,分析纹状体中5-HT合成代谢和分解代谢中各指标的关系,进一步探讨力竭运动后脑5-HT含量及其代谢的动态变化对运动性中枢疲劳发生、发展的影响并分析其机理。方法:大鼠分为两组。力竭运动组大鼠进行一次性游泳运动直至力竭。断头处死,取纹状体测色氨酸(Trp)、5-HT和5-羟吲哚乙酸(5-HIAA)含量,测色氨酸羟化酶(TPH)和单胺氧化酶(MAO)活性,取血清测游离色氨酸(f-Trp)含量。结果:与安静组5-HT含量及其代谢各指标相比,力竭运动组大鼠血清f-Trp含量有下降趋势,其余各指标均呈升高趋势,其中纹状体Trp(P<0.01)和5-HIAA(P<0.001)含量显著升高。结论:(1)力竭运动引起血清Trp透过血脑屏障进入脑中增多,导致血清f-Trp含量下降且纹状体Trp含量增多,激活TPH的活性,增强脑5-HT的合成。(2)运动中5-HT的分解也是增加的,说明力竭运动使5-HT代谢加快,易产生中枢疲劳。提示力竭运动组大鼠在力竭运动后,中枢神经系统抑制过程占优势。
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| 关 键 词： | 力竭运动 中枢疲劳 纹状体 5-羟色胺 |
Effects of Exhausted Exercise on Serotonin content and its catabolism in the Rat Brain Striatum |
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| LIU Bei-bei,; ZHANG Yun-kun.Effects of Exhausted Exercise on Serotonin content and its catabolism in the Rat Brain Striatum[J].Joournal of Nanjing Institute of Physical Education:Natural Science,2008(1). |
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| Authors: | LIU Bei-bei ; ZHANG Yun-kun |
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| Institution: | 1.Nanjing General Hospital of Nanjing Military Command; Nanjing; 210002; Jiangsu; China; 2.Nanjing Institute of Physical Education; 210014; Jiamhsu; China); |
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| Abstract: | To observe the effects of exhausted exercise on serotonin content and its catabolism in the rat brain striatum,analyze the relationships of each indexes in synthesis and decomposition metabolisms in brain striatum,further discuss about the effects of dynamic alteration of serotonin contents and its metabolism after exhausted exercise on the incidence and development of sports central fatigue and analyze its mechanism.The contents of tryptophan,serotonin and 5-hydroxyindole aceticacid in striatum were detect... |
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| Keywords: | exhausted exercise central fatigue striatum serotonin |
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