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| 不同溶剂及配比对碳纳米管辅助薄层色谱拆分盐酸普萘洛尔的影响 | |
| 引用本文： | 姚元香,刘金云,谭新良,彭志光,金杭丹.不同溶剂及配比对碳纳米管辅助薄层色谱拆分盐酸普萘洛尔的影响[J].科技导报(北京),2014,32(1):65-69. |
| 作者姓名： | 姚元香 刘金云 谭新良 彭志光 金杭丹 |
| 作者单位： | 1. 湖南中烟工业有限责任公司技术研发中心, 长沙 410014; 2. 中南大学化学化工学院, 有色资源化学教育部重点实验室, 长沙 410083 |
| 基金项目： | 国家自然科学基金项目(21201181);有色金属资源化学教育部重点实验室开放基金项目(2012-KF-04);湖南省科技计划项目(2012RS4007) |
| 摘 要： | 以羟丙基-β-环糊精、甲基-β-环糊精为手性固定相，氧化多壁碳纳米管为拆分辅助吸附添加剂，采用薄层色谱法拆分了盐酸普萘洛尔对映体。优化得到了最佳展开剂条件，并对展开剂中是否添加冰醋酸进行了比较。当以羟丙基-β-环糊精/氧化多壁碳纳米管为固定相制备薄层色谱板，用于拆分盐酸普萘洛尔时，最佳的展开剂条件为：乙腈/异丁醇（体积比为9:1）混合溶剂中添加体积分数为2%的冰醋酸。当以甲基-β-环糊精/氧化多壁碳纳米管为固定相制备薄层色谱板，用于拆分盐酸普萘洛尔时，最佳的展开剂条件为：乙腈/正丁醇（体积比为1：1）混合溶剂中添加体积分数为2%的冰醋酸。 |
| 关 键 词： | 多壁碳纳米管 β-环糊精衍生物 手性分离 薄层色谱 |
| 收稿时间： | 2013-07-29 |
Effects of Various Solvent Systems and the Ratios on Thin-Layer Chromatographic Enantio-separation of Propranolol Hydrochloride |
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| YAO Yuanxiang;LIU Jinyun;TAN Xinliang;PENG Zhiguang;JIN Hangdan.Effects of Various Solvent Systems and the Ratios on Thin-Layer Chromatographic Enantio-separation of Propranolol Hydrochloride[J].Science & Technology Review,2014,32(1):65-69. | |
| Authors: | YAO Yuanxiang;LIU Jinyun;TAN Xinliang;PENG Zhiguang;JIN Hangdan |
| Institution: | 1. Research and Development Center, China Tobacco Hunan Industrial Corporation, Changsha 410014, China; 2. Key Laboratory of Resources Chemistry of Nonferrous Metals, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China |
| Abstract: | This paper evaluates the hydroxypropyl-β-cyclodextrin or methyl-β-cyclodextrin-based chiral stationary phase, with oxidized multi-walled carbon nanotubes as additional adsorbing materials, for the chiral separation of propranolol hydrochloride enantiomers. The compositions of the developing solvent (acetonitrile/various alcohols), with/without acetic acid, are optimized. The optimal solvent system of acetonitrile/iso-butanol 9/1 (V/V) containing 2% acetic acid (in volume) for hydroxypropyl-β-cyclodextrin/ oxidized multi-walled carbon nanotubes impregnated thin-layer chromatography, and the optimal solvent system of acetonitrile/n-butanol 1/1 (V/V) containing 2% acetic acid (in volume) for methyl-β-cyclodextrin/oxidized multi-walled carbon nanotubes impregnated thinlayer chromatography are obtained. |
| Keywords: | carbon nanotubes β-cyclodextrin derivatives chiral separation thin-layer chromatography |
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