Effect of hyperkalemia on insulin secretion |
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Authors: | R Martinez B Rietberg J Skyler J R Oster G O Perez |
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Institution: | (1) Medical and Research Services, Veterans Administration Medical Center, 33125 Miami, Florida, USA;(2) Department of Medicine, University of Miami School of Medicine, 33125 Miami, Florida, USA;(3) Dialysis Unit (III C), Veterans Administration Medical Center, 1201 N.W. 16th Street, 33125 Miami, Florida |
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Abstract: | Summary The effect of hyperkalemia on insulin secretion remains undefined. We evaluated portal and peripheral insulin levels in anesthetized dogs after infusions of KCl. The mean maximal increase in peripheral plasma potassium at infusion rates of 0.2 mEq/kg/h was 0.68±0.20 mEq/l. There were no significant increases in either portal or peripheral insulin levels. In contrast, in six dogs whose plasma potassium concentration increased in each case by more than 2.0 mEq/l (infusion rate of 0.5 mEq/kg/h), portal insulin levels increased fivefold (p<0.05). We conclude that only marked increases in plasma potassium concentration stimulate pancreatic insulin secretion. |
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Keywords: | Insulin potassium hyperkalemia portal vein glucose |
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