Inhibition of lipid peroxidation by diterpenoid fromPodocarpus nagi |
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| Authors: | H Haraguchi H Ishikawa S Sakai B -P Ying I Kubo |
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| Institution: | (1) Faculty of Engineering, Fukuyama University, Gakuen-cho, 729-02 Fukuyama, (Japan);(2) Department of Environmental Science, Policy and Management, University of California, 94720-3112 Berkeley, California, USA |
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| Abstract: | A diterpenoid, totarol (1), fromPodocarpus nagi was evaluated as an antioxidant. This diterpenoid inhibited autoxidation of linoleic acid. Mitochondrial and microsomal lipid peroxidation induced by Fe(III)-ADP/NADH or Fe(III)-ADP/NADPH were also inhibited. Nagilactone E (2), a norditerpene lactone isolated from the same source, had no antioxidative activity. Furthermore, totarol protected red cells against oxidative hemolysis. This diterpene was shown to be effective in protecting biological systems against oxidative stresses. |
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| Keywords: | Podocarpus nagi totarol lipid peroxidation oxidative stress |
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