| HSP60在大肠腺瘤和大肠癌中表达的临床病理研究 |
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| 引用本文： | 陆爱权,雷树勇,刘景龙.HSP60在大肠腺瘤和大肠癌中表达的临床病理研究[J].广西科学院学报,2007,23(2):110-112,116. |
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| 作者姓名： | 陆爱权 雷树勇 刘景龙 |
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| 作者单位： | 武警广西总队医院病理科,广西南宁,530003;武警广西总队医院病理科,广西南宁,530003;武警广西总队医院病理科,广西南宁,530003 |
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| 摘 要： | 选择大肠癌手术切除癌组织标本56份及同组病例距癌组织外缘 3cm内的癌旁组织标本20份,采用免疫组织化学Elivision Plus二步法检测正常大肠黏膜、癌旁组织、大肠腺瘤和大肠癌中热休克蛋白60(HSP60)的表达.结果HSP60在正常大肠黏膜、癌旁组织、大肠腺瘤、大肠癌中表达阳性率分别为27.78%,40%,77.78%,80.36%.各组间比较,HSP60表达的阳性率具有显著性差异(χ2＝23.314,P＝0.000).HSP60在大肠癌中的表达可能在大肠癌发生发展中发挥作用,特别在大肠癌恶性演进中以及预后预测中具有重要意义,其可能可以作为独立的生物标志物.
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| 关 键 词： | 热休克蛋白60 表达 阳性率 大肠癌 |
| 文章编号： | 1002-7378（2007）02-0110-03 |
| 收稿时间： | 2007-03-15 |
| 修稿时间： | 2007-03-15 |
A Clinical Pathological Study on Expressions of HSP60 in Colorectal Carcinoma and Premalignant Lesion |
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| LU Ai-quan,LEI Shu-yong and LIU Jing-long.A Clinical Pathological Study on Expressions of HSP60 in Colorectal Carcinoma and Premalignant Lesion[J].Journal of Guangxi Academy of Sciences,2007,23(2):110-112,116. |
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| Authors: | LU Ai-quan LEI Shu-yong and LIU Jing-long |
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| Institution: | Department of Pathology, Guangxi Provincial Corps Hospital, Chinese People''s Armed Police Forces, Nanning, Guangxi, 530003, China,Department of Pathology, Guangxi Provincial Corps Hospital, Chinese People''s Armed Police Forces, Nanning, Guangxi, 530003, China and Department of Pathology, Guangxi Provincial Corps Hospital, Chinese People''s Armed Police Forces, Nanning, Guangxi, 530003, China |
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| Abstract: | By means of Elivision Plus immunohistochenistry method,the heat shock protein 60(HSP60) expression in colorectal carcinoma,premalignant lesion and normal tissues is tested.The results showthat the positivity rates of HSP60 in colorectal carcinoma,carcinogenesis and malignant are 27.78%,40%,77.78%,80.36%,respectively.There are sharp differences in HSP60 expression between the colorectal carcinoma group and the normal group.These results suggest that expressions of HSP60 might play a role in progression of carcinoma and prognosis and might be expected to become independent biomarker. |
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| Keywords: | heat shock protein 60 expression positivity rates colorectal carcinoma |
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