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A modified non-homogeneous model for codon preference and primary sequence structure in protein-coding regions
Authors:Han Le  Mo Zhong-xi
Institution:(1) School of Mathematics and Statistics, Wuhan University, 430072 Wuhan, Hubei, China
Abstract:Based on non-homogeneous model, a modified model is proposed. The new model deals with codon preference in protein-coding regions, reflects more accurately the key biological features of the regions. In addition, it is demonstrated, via an example, the modified model offers better solutions than previous model does. Foundation item: Supported by the Zi-qiang Science Foundation of Wuhan University Biography: Han Le (1977-), female, Master candidate, research direction: optimization and bioinformatics
Keywords:Markov chain  transition matrix  base sequence  codon
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