Species-dependent stereospecific serum protein binding of the oral anticoagulant drug phenprocoumon |
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Authors: | W. Schmidt E. Jähnchen |
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Affiliation: | (1) Department of Pharmacology, University of Mainz, Obere Zahlbacher Strasse 67, D-6500 Mainz, (Federal Republic of Germany) |
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Abstract: | Summary 13 mammalian species are classified into 3 clearcut groups with respect to the stereospecific serum proteinbinding of phenprocoumon: 2 groups showing opposed stereospecific binding characteristics and a 3rd group exhibiting no stereospecific binding. Structural differences in the albumin molecule account for these stereospecific differences in serum protein-binding.This research was supported by a grant from the Deutsche Forschungsgemeinschaft (Ja/185/6). |
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