Identification of self peptides bound to purified HLA-B27 |
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| Authors: | T S Jardetzky W S Lane R A Robinson D R Madden D C Wiley |
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| Affiliation: | Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138. |
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| Abstract: | A pool of endogenous peptides bound to the human class I MHC molecule, HLA-B27, has been isolated. Microsequence analysis of the pool and of 11 HPLC-purified peptides provides information on the binding specificity of the HLA-B27 molecule. The peptides all seem to be nonamers, seven of which match to protein sequences in a database search. These self peptides derive from abundant cytosolic or nuclear proteins, such as histone, ribosomal proteins, and members of the 90K heat-shock protein family. |
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