| 医药中间体7-TMCA及其合成头孢哌酮新工艺研究 |
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| 引用本文： | 刘书志,吴英绵,杨波,卜欣立,郭英,尚平.医药中间体7-TMCA及其合成头孢哌酮新工艺研究[J].科学技术与工程,2007,7(21):5502-5504. |
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| 作者姓名： | 刘书志 吴英绵 杨波 卜欣立 郭英 尚平 |
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| 作者单位： | 石家庄职业技术学院,石家庄,050081 |
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| 基金项目： | 致谢：本文得到石家庄职业技术学院、华北制药集团新药研究开发中心、石家庄市科技局的大力支持和帮助,在此表示感谢. |
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| 摘 要： | 介绍了新型医药中间体7-TMCA的结构和用途,并研究了使用7-TMCA合成头孢派酮新工艺,结果表明:8批试验中,使用4.0g 7-TMCA为原料,平均得到4.70 g头孢派酮水盐,质量符合国家药典标准,且室温下放置半年不变色。
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| 关 键 词： | 7-TMCA 头孢派酮 半合成抗生素 |
| 文章编号： | 1671-1819（2007）21-5502-03 |
| 修稿时间： | 2007-06-01 |
Pharmaceutical Intermediate 7-TMCA and the Study of Cefoperazone Synthesis Using this Intermediate as Start Material |
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| LIU Shu-zhi,WU Ying-mian,YANG Bo,BU Xin-li,GUO Ying,SHANG Ping.Pharmaceutical Intermediate 7-TMCA and the Study of Cefoperazone Synthesis Using this Intermediate as Start Material[J].Science Technology and Engineering,2007,7(21):5502-5504. |
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| Authors: | LIU Shu-zhi WU Ying-mian YANG Bo BU Xin-li GUO Ying SHANG Ping |
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| Institution: | Shijiazhuang Vocational College, Shijiazhuang 050081, P. R. China |
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| Abstract: | The structure of the pharmaceutical intermediate 7-TMCA and its position in the synthesis routes of several semi-antibiotics were briefed.The synthesis of cefoperazone from this intermediate was investigated,and the results demonstrated that 4.0 g 7-TMCA can be used to produce about 4.70 g cefoperazone water salt,its quality complies to ChP 2005 and its color remains unchanged(white) after six month exposition to air in the room temperature. |
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| Keywords: | 7-TMCA pharmaceutical intermediate cefoperazone semi-antibiotics |
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