| 蛋白质偶联分析似然算法的实现 |
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| 引用本文： | 刘洪运,王卫东,谭小丹.蛋白质偶联分析似然算法的实现[J].科学技术与工程,2007,7(23):6021-6024. |
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| 作者姓名： | 刘洪运 王卫东 谭小丹 |
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| 作者单位： | 1. 解放军总医院生物医学工程研究室,北京,100853
2. 南方医科大学生物医学工程学院,广州,510515 |
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| 摘 要： | 为构建基于MATLAB语言的蛋白质统计偶联分析系统,利用子集共变显式似然(Explicit Likelihood of Subset Covaria-tion,ELSC)算法并进行实验。所实现的分析系统对GPCR多序列比对(Multiple Sequences Alignment,MSA)中的Leu-152位点进行统计偶联分析的结果和已有生物学实验结果吻合,验证了系统的正确性和实用性。
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| 关 键 词： | 统计偶联分析 多序列比对 似然 |
| 文章编号： | 1671-1819(2007)23-6021-04 |
| 修稿时间： | 2007-08-30 |
Implementation of Explicit Likelihood of Subset Co-variation on Coupling Analysis of Proteins |
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| LIU Hong-yun,WANG Wei-dong,TAN Xiao-dan.Implementation of Explicit Likelihood of Subset Co-variation on Coupling Analysis of Proteins[J].Science Technology and Engineering,2007,7(23):6021-6024. |
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| Authors: | LIU Hong-yun WANG Wei-dong TAN Xiao-dan |
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| Institution: | Department of Biomedical Engineering, General Hospital of Chinese PLA, Beijing 100853, P. R. China; School of Biomedical Engineering, South University of Medical Science , Guangzhou 510515 ,P. R. China |
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| Abstract: | Utilizing the explicit likelihood of subset co-variation (ELSC) algorithm, the statistical coupling analysis system (SCAS) is designed based on MATLAB programming language. Making use of ELSC algorithm and making experiments, by applying the SCAS to Leu-152 position in the GPCR MSA, the amino acid positions coupled with Leu-152 position are predicted. The result accords with the conclusions obtained by the biology experiments approximately. As a result, the validity and practicability of the SCAS are proved. |
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| Keywords: | statistical coupling analysis multiple sequence alignment likelihood |
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