Demonstration of an alpha adrenergic effect on the adipocytes of dog adipose tissue]

Phentolamine, an alpha blocking agent, potentializes the adrenergical lipolytic effect of isolated fat cells of Canine omental adipose tissue when their average diameter is greater than 80 micrometers. This effect can be found also in isolated fat cells of mesenteric adipose tissue, spontaneously less sensitive with catecholamines. Phenylephrine, alpha sympathomimetic, partially inhibits the lipolytic effect stimulated by isoprenaline.