| Characteristics of fMRI BOLD signal and its neurophysiological mechanism |
| |
| 作者姓名： | Zhao Xiaohu Wu Yigen and Guo Shengli |
| |
| 作者单位： | 1. College of Life Sciences，Zhejiang University，Hangzhou 310058，China; 2. Imaging Department of Tongji Hospital of Tongji University，Shanghai 200065，China; 3. College of Mathematics and Physics，Nanjing University of Information Science and Technology，Nanjing 210044，China |
| |
| 基金项目： | Supported by National Natural Science Foundation of China (Grant Nos 30570538 ,30400103 and 30470517) |
| |
| 摘 要： | The functional magnetic resonance imaging (fMRI) based on blood oxygen level dependent (BOLD) contrast has emerged as one of the most potent noninvasive tools for mapping brain function and has been widely used to explore physiological, pathological changes and mental activity in the brain. Exploring the nature and property of BOLD signal has recently attracted more attentions. Despite that great progress has been made in investigation of the characteristics and neurophysiological basis, the exact nature of BOLD signal remains unclear. In this paper we discuss the characteristics of BOLD signals, the nonlinear BOLD response to external stimuli and the relation between BOLD signals and neural electrophysiological recordings. Furthermore, we develop our new opinions regarding nonlinear BOLD response and make some perspectives on future study.
|
Characteristics of fMRI BOLD signal and its neurophysiological mechanism |
| |
| Authors: | Zhao Xiaohu Wu Yigen and Guo Shengli |
| |
| Institution: | 1. College of Life Sciences, Zhejiang University, Hangzhou 310058, China; 2. Imaging Department of Tongji Hospital of Tongji University, Shanghai 200065, China; 3. College of Mathematics and Physics, Nanjing University of Information Science and Technology, Nanjing 210044, China |
| |
| Abstract: | The functional magnetic resonance imaging (fMRI) based on blood oxygen level dependent (BOLD) contrast has emerged as one of the most potent noninvasive tools for mapping brain function and has been widely used to explore physiological, pathological changes and mental activity in the brain. Exploring the nature and property of BOLD signal has recently attracted more attentions. Despite that great progress has been made in investigation of the characteristics and neurophysiological basis, the exact nature of BOLD signal remains unclear. In this paper we discuss the characteristics of BOLD signals, the nonlinear BOLD response to external stimuli and the relation between BOLD signals and neural electrophysiological recordings. Furthermore, we develop our new opinions regarding nonlinear BOLD response and make some perspectives on future study. |
| |
| Keywords: | functional magnetic resonance imaging blood oxygen level dependent nonlinear response neural electrophysiological activity |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《自然科学进展》浏览原始摘要信息 |
| 点击此处可从《自然科学进展》下载免费的PDF全文 |
