Insensitivity of the ferritin iron core to heat treatment

Summary To test whether the reactivity of ferritin iron is affected by the heat treatment used in ferritin isolation, we prepared ferritin from the same horse spleen with or without heating. Both samples exhibited similar reactivity upon reduction or chelation of iron.Acknowledgments. We are indebted to George Rossman who brought this problem to our attention. Work was supported in part by NIH Grant HL20141 and by the Petroleum Research Fund.