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The influence of GABA on discharges of cortical epileptogenic focus
Authors:P Mareš  J Mareš  P Remeš  M Hessler  J Fischer
Institution:(1) Institute of Physiology, Czechoslovak Academy of Sciences, Budecaronjovická 1083, CS-142 20 Prague 4;(2) Institute of Physiology, Faculty of General Medicine, Charles University, Prague, (Czechoslovakia)
Abstract:Summary GABA, when applied locally, acted similarly on both primary and mirror cortical focus: the negative component of the spike discharge was suppressed or inverted in polarity, whereas the late slow negative wave was strongly potentiated. Recordings from deep cortical layers suggested a different origin of these 2 surface-negative components of focal discharges.
Keywords:
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