Pimozide and pyrogen-induced fever in rabbits |
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| Authors: | I R Pela C Gardey-Levassort P Lechat |
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| Institution: | (1) Laboratorie Associé du C. N. R. S. no 206, Institut de Pharmacologie, 21, rue de l'Ecole de Médecine, 75006 Paris, France;(2) Present address: Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP), Brazil |
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| Abstract: | Summary Pimozide, a selective blocker of DA receptors, partly inhibits but does not suppress either the DA-induced hyperthermia or the LPS-induced fever in rabbits. This suggests that a common DA-related mechanism could be at least partly involved in both responses.Acknowledgments. We wish to thank Laboratories Le Brun (Paris) for the generous supply of pimozide. |
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