Percutaneous penetration of indomethacin |
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| Authors: | H. Ishihama H. Kimata Y. Mizushima |
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| Affiliation: | (1) Tokyo Research Laboratories, Kowa Co. Ltd, Higashimurayama, 189 Tokyo, Japan;(2) The 1st Department of Internal Medicine, St. Marianna University School of Medicine, Takatsu-ku, 213 Kawasaki, Japan |
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| Abstract: | Summary 14C-Indomethacin (ID) was applied to the skin of guinea-pigs as an ointment. After several applications, the concentration of ID in the skin and muscle under the applied site reached a constant level. The concentration of ID in the muscle as well as the skin may be enough to exert an anti-inflammatory effect. |
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