| 由聚苯乙烯负载烯基硒醚固相合成(E)-1,2-二取代乙烯 |
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| 引用本文： | 刘晓玲,余利明,盛寿日,宋才生.由聚苯乙烯负载烯基硒醚固相合成(E)-1,2-二取代乙烯[J].江西师范大学学报(自然科学版),2002,26(3):232-234. |
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| 作者姓名： | 刘晓玲 余利明 盛寿日 宋才生 |
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| 作者单位： | 1. 江西师范大学,化学与生物科学学院,江西,南昌,330027
2. 浙江大学西溪校区,化学系,浙江,杭州,310028 |
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| 基金项目： | 江西省自然科学基金(001109)和江西师范大学科研基金资助课题. |
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| 摘 要： | 聚苯乙烯负载硒溴与炔基锂反应合成聚苯乙烯负载炔基硒醚，再与LiAIH4反应制得聚苯乙烯负载反式烯基硒醚；此负载型烯基硒醚在NiCl2(PPh3)2存在下与格氏试剂发生的偶联反应，提供了一种有效的（E）-1，2二取代乙烯的固相有机合成方法。
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| 关 键 词： | 固相有机合成 聚苯乙烯负载烯基硒醚 格氏试剂 偶联反应 （E）－1 2－二取代乙烯 绿色化学 |
| 文章编号： | 1000-5862(2002)03-0232-03 |
Solid-Phase Synthesis of (E)-1,2-Disubstituted Ethenes by Polystyrene-Supported Vinyl Selenides |
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| LIU Xiao-ling ,YU Li-ming ,SHENG Shou-ri ,SONG Cai-sheng.Solid-Phase Synthesis of (E)-1,2-Disubstituted Ethenes by Polystyrene-Supported Vinyl Selenides[J].Journal of Jiangxi Normal University (Natural Sciences Edition),2002,26(3):232-234. |
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| Authors: | LIU Xiao-ling YU Li-ming SHENG Shou-ri SONG Cai-sheng |
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| Institution: | LIU Xiao-ling 1,YU Li-ming 2,SHENG Shou-ri 1,SONG Cai-sheng 1 |
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| Abstract: | Treatment of polymer-supported selenium bromide with lithium acetylides afforded polymer-supported selenoacetylene, which reacted with LiAlH 4 giving a way for stereoselective synthesis of polymer-supported (E)- vinylic selenides. Cross-coupling reaction of polymer-supported (E)- vinylic selenides with Grignard reagents in the presence of NiCl 2(PPh 3) 2 as catalyzed yielded (E)-1,2-disubstituted ethenes on solid-phase. |
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| Keywords: | solid-phase organic synthesis polymer-supported vinylic selenides Grignard reagents cross-coupling reaction (E)-1 2-disubstituted ethenes |
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