A study of vasoactive intestinal polypeptide (VIP) stimulated intestinal fluid secretion in rat and its inhibition by indomethacin |
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| Authors: | R H Albuquerque C W I Owens S R Bloom |
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| Institution: | (1) Royal Postgraduate Medical School, Du Cane Road, W12 OHS London;(2) University College Hospital Medical School, University Street, WC1E 6JJ London, (England) |
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| Abstract: | Summary 4 groups of rats were studied under anaesthesia to assess the effect of VIP and the influence of the prostaglandin synthetase inhibitor indomethacin in isolated bowel loops. VIP produced a highly significant increase in the luminal fluid content and this was completely inhibited by addition of indomethacin. |
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