Ca-antagonistic substance from soft coral of the genusSarcophyton |
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| Authors: | J Kobayashi Y Ohizumi H Nakamura T Yamakado T Matsuzaki Y Hirata |
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| Institution: | (1) Mitsubishi-Kasei Institute of Life Sciences, 11 Minamiooya, Machida-shi, 194 Tokyo, (Japan);(2) Research Center, Mitsubishi Chemical Industries Ltd, Kamoshida, Midori-ku, 227 Yokohama, (Japan);(3) Faculty of Pharmacy, Meijo University, Tempaku, 468 Nagoya, (Japan) |
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| Abstract: | Summary A 14-membered ring diterpenoid named cembrane, possessing Ca-antagonistic action on the isolated rabbit aorta, has been isolated from a soft coral of the genusSarcophyton, and its structure established by X-ray and spectroscopic data.The authors thank Mr. Z. Nagahama (Okinawa) for collection of soft corals, Miss R. Abe (the present institute) for her skillful assistance, and Dr. T. Higashijima, Prof. T. Miyazawa (Tokyo University), Mr. T. Hayase and Dr. H. Ohtani (Mitsubishi Chemical Industries Ltd) for1H and13C NMR-measurements. |
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