Effect of benzo[a]pyrene on friend virus leukemogenesis,CFU-S viability,and induction of humoral immunity |
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| Authors: | R. B. Raikow J. P. OKunewick M. J. Buffo D. L. Jones |
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| Affiliation: | (1) Cancer Research Laboratories, allegheny-Singer Research Corporation, Allegheny General Hospital, 15212 Pittsburgh, PA, USA |
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| Abstract: | Summary Benzo[a]pyrene (BP) potentiated the induction of leukemia by low doses of Friend virus in SJL/J mice if injected 2 days before the virus. BP also reduced the viability of hematopoietic stem cells (CFU-S) within this time interval but had little effect on the induction of humoral immunity (the PFC response).This work was supported by Department of Energy Contract No. EP-78-S-02-4800. |
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