The effect of activated dimethicone,other antacid constituents,and kaolin on the absorption of propranolol |
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Authors: | J C McElnay P F D'Arcy J K Leonard |
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Institution: | (1) Department of Pharmacy, The Queen's University of Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL Belfast, (Northern Ireland) |
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Abstract: | Summary A study was made of the effect of 6 commonly used gastrointestinal preparations on the absorption of propranolol using an
in vitro experimental model. The constituents examined were activated dimethicone, aluminium hydroxide gel, bismuth carbonate,
kaolin, magnesium carbonate, and magnesium trisilicate. A slight decreased propranolol absorption was given by kaolin (−13.0%),
the other components showed smaller effects ranging from −6.8% to +6.6%. None of the results were statistically significantly
different from control absorption values.
Acknowledgment. We are grateful to I.C.I. Ltd, Macclesfield, England, for the gift of propranolol hydrochloride and to Galen
Ltd, Craigavon, Northern Ireland, for the gift of dimethicone. |
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Keywords: | |
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