Morphofunctional changes in the mitochondrial subpopulations of conceptus tissues during the placentation process |
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Authors: | Justo R Alcolea M P Colom B Riera A N Gianotti M García-Palmer F J |
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Institution: | (1) Energy Metabolism and Nutrition Research Group, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Cra. Valldemossa km 7.5, E-07071 Palma de Mallorca (Spain), Fax + 34 971 173184, e-mail: , ES |
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Abstract: | To establish the role of mitochondrial subpopulations in the mitochondrial maturation process, we studied morphological and
functional changes in the mitochondria of different mammalian conceptus tissues during the organogenic and the placentation
processes. Mitochondrial subpopulations of three different conceptus tissues, embryo and visceral yolk sac placenta on gestational
days 11, 12 and 13 and placenta on days 12 and 13, were examined morphologically by transmission electron microscopy. Cytochrome
oxidase activity and protein levels were also measured in each mitochondrial subpopulation. The results indicate two different
mitochondrial subpopulation profiles: a homogeneous one, which corresponds to immature mitochondria, and a heterogeneous one,
which represents the mature mitochondria. The three tissues studied show different morphologic and metabolic patterns of mitochondrial
maturation during the placentation process, rendering them suitable as experimental models to establish the p
ossible relationship between mitochondrial maturation and the mitochondrial subpopulations.
Received 5 August 2002; received after revision 23 September 2002; accepted 8 October 2002
RID="*"
ID="*"Corresponding author. |
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Keywords: | , Embryo, visceral yolk sac, placenta, mitochondrial subpopulation, mitochondrial morphology, cytochrome c oxidase, |
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