| TNF和OA诱发人神经母细胞瘤SK细胞程序死亡 |
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| 引用本文： | 陈亚兵. TNF和OA诱发人神经母细胞瘤SK细胞程序死亡[J]. 厦门大学学报(自然科学版), 1996, 35(4): 597-599 |
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| 作者姓名： | 陈亚兵 |
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| 作者单位： | 肿瘤细胞工程国家专业实验室 |
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| 摘 要： | 肿瘤坏死因子（ＴＮＦ）和Ｏｋａｄａｉｃａｃｉｄ（ＯＡ）能诱发人神经母细胞瘤ＳＫ细胞死亡，死亡细胞缩小变圆，细胞质凝聚，ＤＮＡ断裂形成以２００ｂＰ左右为单位的梯形分布，且上述过程可由蛋白质合成抑制剂亚胺环己酮（ＣＨＸ）抑制，显示ＴＮＦ和ＯＡ诱发的ＳＫ细胞死亡为细胞程序死亡．
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| 关 键 词： | 肿瘤坏死因子，Okadaicacid，细胞程序死亡 |
TNF and OA Induced the Programmed Cell Death of the Human Neuroblastoma SK Cell |
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| Chen Yabing,Yu Chundong ,Cai Yu Zeng Guisheng, Wen Longping. TNF and OA Induced the Programmed Cell Death of the Human Neuroblastoma SK Cell[J]. Journal of Xiamen University(Natural Science), 1996, 35(4): 597-599 |
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| Authors: | Chen Yabing Yu Chundong Cai Yu Zeng Guisheng Wen Longping |
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| Affiliation: | State Lab. for Tumor Cell Engr. |
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| Abstract: | TNF and OA can induce cell death in the human nurobiastoma SK cell line with the characteristic features of apoptosis. Cells are rounded and shrink;cytoplasm condenses; DNA is fragmented into a 200 bp ladder. Moreover,the above phenomenon can be partially inhibited by protein synthesis inhibitor cycloheximide. |
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| Keywords: | TNF Okadaic acid Programmed cell death |
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