| Genomic organization and sequence analysis of the vomeronasal receptor V2R genes in mouse genome |
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| 作者姓名： | YANG Hui Zhang YaPing |
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| 作者单位： | [1]Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China [2]Graduate University of the Chinese Academy of Sciences, Beijing 100049, China [3]Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming 650091, China |
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| 基金项目： | Supported by National Natural Science Foundation of China （Grant Nos. 30430110 and 30021004）, and Yuunan Bureau of Science and Technology.The authors thank Wu DongDong for his effort in the chromosome map drawing. |
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| 摘 要： | Two multigene superfamilies, named V1R and V2R, encoding seven-transmembrane-domain G-protein coupled receptors (GPCRs) have been identified as pheromone receptors in mammals. Three V2R gene families have been described in mouse and rat. Here we screened the updated mouse genome se- quence database and finally retrieved 63 putative functional V2R genes including three newly identified genes which formed a new additional family. We described the genomic organization of these genes and also characterized the conservation of mouse V2R protein sequences. These genomic and se- quence information we described are useful as part of the evidence to speculate the functional domain of V2Rs and should give aid to the functionality study in the future.
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| 关 键 词： | 大白鼠 基因组 犁鼻受体2 多基因超家族 序列分析 |
| 收稿时间： | 5 June 2006 |
| 修稿时间： | 2006-06-05 |
Genomic organization and sequence analysis of the vomeronasal receptor V2R genes in mouse genome |
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| YANG Hui Zhang YaPing.Genomic organization and sequence analysis of the vomeronasal receptor V2R genes in mouse genome[J].Chinese Science Bulletin,2007,52(3):336-342. |
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| Authors: | Hui Yang YaPing Zhang |
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| Institution: | (1) Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China;(2) Graduate University of the Chinese Academy of Sciences, Beijing, 100049, China;(3) Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, 650091, China |
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| Abstract: | Two multigene superfamilies, named V1R and V2R, encoding seven-transmembrane-domain G-protein coupled receptors (GPCRs) have been identified as pheromone receptors in mammals. Three V2R gene families have been described in mouse and rat. Here we screened the updated mouse genome se- quence database and finally retrieved 63 putative functional V2R genes including three newly identified genes which formed a new additional family. We described the genomic organization of these genes and also characterized the conservation of mouse V2R protein sequences. These genomic and se- quence information we described are useful as part of the evidence to speculate the functional domain of V2Rs and should give aid to the functionality study in the future. |
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| Keywords: | mouse vomeronasal receptor 2 (V2R) gene family |
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