基于高压静电技术的戊唑醇/乙酸纤维素缓释剂的制备与性能研究 |
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引用本文: | 徐鹏,高娟,王利莹,梁娟,唐进根. 基于高压静电技术的戊唑醇/乙酸纤维素缓释剂的制备与性能研究[J]. 南京林业大学学报(自然科学版), 2016, 59(6): 117-121. DOI: 10.3969/j.issn.1000-2006.2016.06.018 |
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作者姓名: | 徐鹏 高娟 王利莹 梁娟 唐进根 |
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作者单位: | 1. 南京林业大学化学工程学院,江苏 南京 210037;2. 南京林业大学林学院,江苏 南京 210037 |
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基金项目: | 江苏省自然科学基金(青年基金)项目(BK20130969) |
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摘 要: | 以戊唑醇(TBA)为模型药物,可生物降解的乙酸纤维素(CA)为载体材料,利用高压静电技术,制备了载药微球和载药纳米纤维缓释剂,并对载药微球和载药纳米纤维的释放过程进行了研究,同时采用扫描电子显微镜、红外光谱仪对载药微球和载药纳米纤维的结构和形貌进行了表征。结果表明,在缓释剂制备过程中,CA溶液浓度对载药缓释剂的形貌有较大的影响,CA溶液质量分数为4%时,制得的缓释剂为球形结构; CA溶液质量分数为15%时,制得的缓释剂为纳米纤维结构。载药微球和载药纳米纤维均具有一定的缓释性能,对白色念珠菌具有明显的抗菌效果。
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关 键 词: | 缓释剂 高压静电技术 乙酸纤维素 戊唑醇 抗菌 |
Preparation and research of tebuconazole-loaded cellulose acetate slow-release formulation by high voltage electrostatic technology |
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Abstract: | In this paper, the tebuconazole(TBA)was loaded on the cellulose acetate(CA)that is one of the biodegradable materials.The TBA-loaded microspheres and nano-fibers slow-release agents were prepared using the high voltage electrostatic technology. The release processes of the TBA-loaded microspheres and nano-fibers were also investigated. The structures and morphologies of the TBA-loaded microspheres and nano-fibers were characterized by the scanning electron microscopy, infrared spectrometer and laser particle size analyzer. Research results indicated that the concentration of cellulose acetate solution exerted a great influence on the structure of TBA release systems. The TBA-loaded microspheres were fabricated at a CA concentration of 4%, and the TBA-loaded nano-fibers were made at a CA concentration of 15%. Both the TBA-loaded microspheres and nano-fibers showed the slow-release property, and exerted definite antibacterial effect on the Candida albicans. |
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Keywords: | slow-release agent high voltage electrostatic technology cellulose acetate(CA) tebuconazole(TBA) antibacterial |
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