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Der Einfluss von Calcium auf die Brenzcatechinaminfreisetzung |
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| Authors: | A Philippu H J Schümann |
| Institution: | (1) Pharmakologisches Institut der Universität Frankjurt am Main, Deutschland |
| Abstract: | Summary (1) Experiments on isolated perfused suprarenals of cattle have shown that the acetylcholine-induced release of catechol amines, but not that of phenylethylamine, is dependent on calcium, since a perfusion with calcium-free Tyrode's solution abolishes the action of acetylcholine and not that of phenylethylamine. (2) Inincubation experiments with isolated chromaffin granules, calcium produces a dose-dependent, significant release of catechol amines even in physiological concentrations (2.5 mM). (3) Acetylcholine does not release catechol amines from isolated granules, either in the presence or in the absence of calcium. Forschungs-Stipendiat der A. von Humboldt-Stiftung. Ausgeführt mit Unterstützung der Deutschen Forschungsgemeinschaft. |
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