| L-脯氨酰胺衍生物的合成及在不对称催化反应中的应用 |
| |
| 引用本文： | 李清寒,丁勇,赵志刚,张刚,陈峰. L-脯氨酰胺衍生物的合成及在不对称催化反应中的应用[J]. 西南民族学院学报(自然科学版), 2014, 0(4): 499-503 |
| |
| 作者姓名： | 李清寒 丁勇 赵志刚 张刚 陈峰 |
| |
| 作者单位： | 西南民族大学化学与环境保护工程学院,四川成都610041 |
| |
| 基金项目： | 西南民族大学中央高校基本科研业务费专项基金（No.12NZYTD03）;西南民族大学2013年研究生学位点建设项目（No.2013XWD-S0703）;西南民族大学校学术带头人培养基金（No.381010）. |
| |
| 摘 要： | 以L-脯氨酸为原料,与不同的手性胺基醇及脂肪胺反应合成了6个手性酰胺化合物,并考查了它们在醛的不对称烷基化反应及炔酯与三甲基铝的不对称偶联反应中的催化性能,结果表明6个化合物均有一定的催化效果.所有目标化合物均通过熔点测定和核磁共振氢谱及碳谱分析对其结构进行确证.
|
| 关 键 词： | L-脯氨酰胺 不对称烷基化 不对称偶联 |
Synthesis and application of L-Pyrrolidine-2-carboxamide derivatives in asymmetric catalytic reaction |
| |
| LI Qing-han,DING Yong,ZHAO Zhi-gang,ZHANG Gang,CHEN Feng. Synthesis and application of L-Pyrrolidine-2-carboxamide derivatives in asymmetric catalytic reaction[J]. Journal of Southwest Nationalities College(Natural Science Edition), 2014, 0(4): 499-503 |
| |
| Authors: | LI Qing-han DING Yong ZHAO Zhi-gang ZHANG Gang CHEN Feng |
| |
| Affiliation: | ( School of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041, P.R.C. ) |
| |
| Abstract: | Six L-Pyrrolidine-2-carboxamide derivatives 3（a-d,f,g） were synthesized from L-Pyrrolidine-2-carboxylic acid react with different chiral aminoalcohol and aliphatic amino. Their catalysis was evaluated in asymmetric alkylation of aldehydes and asymmetric cross-coupling ofpropargylic carbonates react with Trimethylaluminum. The result indicated that the compounds exhibited different catalysis in asymmetric catalytic reaction. Their structures have been determined by IH NMR and ^13C NMR data. |
| |
| Keywords: | L-Pyrrolidine-2-carboxamide derivative asymmetric alkylation asymmetric cross-coupling |
| 本文献已被 CNKI 维普 等数据库收录！ |
